PSME2 Antilichaam

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.

5721

Q9UL46

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 1-239 of human PSME2 (NP_002809.2) .

Unconjugated

Primary Antibodies

Cell Cycle

Affinity purification

U-251MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 27kDa

IgG

PSME2

Mouse thymus

Mouse lung

Mouse kidney

Proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

Homo sapiens

PSME2, proteasome (prosome, macropain) activator subunit 2 (PA28 beta), PA28B, PA28beta, REGbeta, 11S regulator complex beta subunit, MCP activator, 31-kD subunit, activator of multicatalytic protease subunit 2, cell migration-inducing protein 22, proteasome activator 28-beta, proteasome activator hPA28 subunit beta, proteasome activator subunit 2

WB, IHC

Liquid