[Pt (DACH) (OH) 2 (ox) ]

[Pt (DACH) (OH) 2 (ox) ] (Dihydroxy Oxaliplatin-Pt (IV) ) is a Oxaliplatin -based Pt (IV) scaffold. [Pt (DACH) (OH) 2 (ox) ] reacts with N-hydroxysuccinimide (NHS) ester of Pyropheophorbide-a (HY-128973) to yield phorbiplatin. Phorbiplatin is a highly potent Pt (IV) antitumor prodrug[1].

111321-67-6

Dihydroxy Oxaliplatin-Pt (IV)

12352300

H290-H301-H311-H315-H319-H331-H335-H340-H350

Drug Intermediate

Others

Cancer-programmed cell death

Cancer

[OH-][Pt+4]12([NH2][C@@]3([H])[C@](CCCC3)([H])[NH2]1)([O-]C(C([O-]2)=O)=O)[OH-]

C8H16N2O6Pt

431.31

P234-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P390-P403+P233-P405-P406-P501

[1]Wang Z, et al. Phorbiplatin, a highly potent Pt (IV) antitumor prodrug that can be controllably activated by red light. Chem, 2019, 5 (12) : 3151-3165.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W778423/

Reference compound1

No Development Reported