PTBP1 Antilichaam - N-terminalgebied: FITC (ARP40421_P050-FITC)

Polypyrimidine tract binding protein 1

PTB, PTB2, PTB3, PTB4, pPTB, HNRPI, PTB-1, PTB-T, HNRNPI, HNRNP-I

5725

P26599

NP_114368

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human PTBP1

PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) . The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) . These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) . The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) . These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

UBC; SNRPA; SFPQ; PTBP1; NONO; LGR4; MDM2; RPA3; RPA2; RPA1; BMI1; SUZ12; EED; RNF2; DIMT1; YBX3; AIMP2; SPTAN1; RPS27; QARS; YBX1; RPSA; ILF2; HNRNPU; HNRNPD; HNRNPA2B1; FAU; EPRS; EIF4G1; APBB1; ABCF1; NELFB; G3BP1; AIMP1; EIF2B2; IQGAP1; TARDBP; SRPK2

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

PTBP1 is strongly supported by BioGPS gene expression data to be expressed in Daudi

0.5 mg/ml

Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 91%; Rat: 100%; Zebrafish: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

58kDa

Robinson, F. (2006) J. Biol. Chem. 281 (2), 800-806

Wet Ice

531

PTBP1

PTBP1

Rabbit

Polypyrimidine tract-binding protein 1

NM_031991

RGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRVIHI