PTCH1 Antilichaam

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

5727

Q13635

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1214-1312 of human PTCH1 (NP_000255.2) .

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Neuroscience, Signal Transduction, Stem Cell

Affinity purification

293T

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 160kDa

IgG

PTCH1

Mouse liver

Patched 1

Homo sapiens

PTCH1, PTC, BCNS, HPE7, PTC1, PTCH, NBCCS, PTCH11

WB, IF

Liquid