PTCH1 Mouse Monoclonal Antibody [Kloon ID: LBI6C10]

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) PTCH1 mouse monoclonal antibody, clone LBI6C10

BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11

Homo sapiens patched 1 (PTCH1), transcript variant 1b, mRNA.

5727

Q13635

Unconjugated

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

WB 1:2000

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

PTCH1

https://www.ncbi.nlm.nih.gov/gene/?term=5727

https://www.uniprot.org/uniprot/Q13635