PTGDR2 Antilichaam

PTGDR2 Antibody: The prostaglandin D2 receptor 2 (PTGDR2), also known as CRTH2, is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, PTGDR2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the PTGDR2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that PTGDR2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo.

11251

Q9Y5Y4

NP_004769

Human, Mouse

Unconjugated

Primary Antibodies

Immunology

PTGDR2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1308 - Human Small Intestine Tissue Lysate

1 mg/mL

PTGDR2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PTGDR2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 43 kDa

IgG

PTGDR2

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Prostaglandin D2 receptor 2

Homo sapiens

Nagata K, Hirai K, Tanaka K, et al. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor (s) . FEBS Lett. 1999; 459:195-9.

Shichijo M, Sugimoto H, Nagao K, et al. Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockage abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats. J. Pharmacol. Exp. Ther. 2003; 307:518-25.

Chevalier E, Stock J, Fisher T, et al. Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. J. Immunol. 2005; 2056-60.

PTGDR2 Antibody: DP2, DL1R, CD294, CRTH2, GPR44, Prostaglandin D2 receptor 2, Chemoattractant receptor-homologous molecule expressed on Th2 cells

ELISA, WB, IF

153791424

Liquid