PTK2B Antilichaam - C-terminal regio : HRP (ARP32685_P050-HRP)

PTK2B protein tyrosine kinase 2 beta

PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK

2185

Q14289

NP_004094

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human PTK2B

PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.

CBLB; UBC; EGFR; PXN; HSP90AA1; MAPT; GP6; TRAF4; BCAR1; SKAP2; GP1BB; UL49; SOCS3; SRC; GRB2; FYN; DNM1; ALG2; SH3KBP1; PDCD6IP; CBL; SOCS2; PTEN; MBD2; DLGAP3; STAP1; SORBS2; NEDD9; EFS; NPHP1; PITPNM2; PITPNM3; PITPNM1; ARHGAP21; RB1CC1; ASAP1; LPXN; P

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

116kDa

Ling, S., et al., (2004) Am. J. Physiol., Cell Physiol. 287 (3), C698-C706

Wet Ice

1009

PTK2B

PTK2B

Rabbit

Protein-tyrosine kinase 2-beta

NM_004103

KSPLTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMEL