PTK6 Antilichaam [2H12B8]

PTK6 (protein tyrosine kinase 6, BRK or FLJ42088), with 451-amino acid protein (about 51 kDa), encods a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Its presence in the nucleus appears to be linked to suppression of tumor progression. The encoded protein has been shown to undergo autophosphory-lation. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. And Expressed at low level in some breast tumors, but not in normal breast. Also found in melanocytes, but not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype.

5753

Q13882

Q13882

Human

Ni-NTA purified truncated recombinant PTK6 expressed in E. Coli strain BL21 (DE3) .

2H12B8

Unconjugated

Primary Antibodies

Signal Transduction

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

PTK6 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG2b

PTK6

Protein tyrosine kinase 6

Homo sapiens

Wilks, A.F. Proc. Natl. Acad. Sci. USA 86: 1603-1607.

Ottilie, S., et al. Oncogene 7: 1625-1630.

Lee, S.T., et al. Oncogene 8: 3403-3410.

BRK, Breast tumor kinaseBRK

ELISA

8928302