PTP1B (PTPN1) Mouse Monoclonal Antibody [Kloon ID: LBI2G3]

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq]

Carrier-free (BSA/glycerol-free) PTPN1 mouse monoclonal antibody, clone LBI2G3

PTP1B

Homo sapiens protein tyrosine phosphatase non-receptor type 1 (PTPN1), transcript variant 1, mRNA.

5770

P18031

Unconjugated

Adherens junction, Insulin signaling pathway

Adherens junction, Insulin signaling pathway

WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Phosphatase, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

PTPN1

https://www.ncbi.nlm.nih.gov/gene/?term=5770

https://www.uniprot.org/uniprot/P18031