PTP4A2 Antilichaam

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17.

8073

Q12974

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 30-100 of human PTP4A2 (NP_536316.1) .

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Signal Transduction

Affinity purification

MCF7

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 19kDa

IgG

PTP4A2

Mouse skeletal muscle

Mouse brain

Mouse kidney

Mouse liver

Rat brain

Protein tyrosine phosphatase type IVA 2

Homo sapiens

Protein tyrosine phosphatase type IVA 2, HU-PP-1, OV-1, PTP (CAAXII), Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2, PRL-2, PTP4A2, PRL2, PTPCAAX2

WB, IHC

Liquid