PTPN11 Antilichaam - N-terminalgebied: HRP (ARP56494 P050-HRP)

Protein tyrosine phosphatase, non-receptor type 11

CFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2, SH-PTP3

5781

Q06124-2

NP_002825

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human PTPN11

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

TRIM32; RPIA; UBC; NEDD8; SUMO1; MTPN; EFHD2; CHRAC1; OXCT1; MAPK14; GRB2; Siglece; GAB2; GAB1; VCAM1; CD274; IQCB1; IRS1; ERBB2; EGFR; FASN; RFWD2; FRS2; PPIF; GSK3B; CRK; PIK3R2; PIK3R1; MAP3K5; LRRK1; CSF2RBP1; FYN; CBL; SOCS3; CXCR4; MYC; INPP5D; IL6S

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

68kDa

Wet Ice

593

PTPN11

PTPN11

Rabbit

Tyrosine-protein phosphatase non-receptor type 11

NM_002834

HPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTD