PTPN13 Antilichaam

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBα through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

5783

Q12923

NP_006255.1

Human

212-399

Unconjugated

Primary Antibodies

Other

Immunoaffinity Purified

1 mg/mL

Phosphate-Buffered Saline. No preservatives added.

None

Blue Ice

PTPN13 antibody can be stored at 4˚ C for short term (weeks) . Long term storage should be at -20˚ C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

14.2 kDa (calculated)

Protein-tyrosine phosphatase antibody can be used for the detection of Protein-tyrosine phosphatase by Western Blot.

PTPN13

Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas) -associated phosphatase)

Homo sapiens

PNP1, PTP1E, PTPL1, Tyrosine-protein phosphatase non-receptor type 13, Fas-associated protein-tyrosine phosphatase 1, FAP-1, PNP1, PTPLE, PTP-BL, hPTP1E, PTP-BAS, Proteintyrosine phosphatase

WB

5453992

Liquid