PTPN5 Antilichaam

The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1) . It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2) . NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3) . Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4,5) . PTPN5 may play a role in Alzheimer's disease (1) .

84867

Q86TL6

NP_008837

Human, Mouse

Unconjugated

Primary Antibodies

Neuroscience

PTPN5 antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/mL

PTPN5 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PTPN5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

PTPN5 antibody is human and mouse reactive.

PTPN5

Protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)

Homo sapiens

Braithwaite SP, Paul S, Nairn AC, et al. Synaptic plasticity: one STEP at a time. Trends Neurosci. 2006; 29:452-8.

Paul S, Snyder GL, Yokakura H, et al. The Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase STEP via a PKA-dependent pathway. J. Neurosci. 2000; 20:5630-8.

Paul S, Nairn AC, Wang P, et al. NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat. Neurosci. 2003; 6:34-42.

Braithwaite SP, Adkisson M, Leung J, et al. Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP) . Eur. J. Neurosci. 2006; 23:2847-56.

Tyrosine-protein phosphatase non-receptor type 5, Neural-specific protein-tyrosine phosphatase, PTPSTEP, Striatum-enriched protein-tyrosine phosphatase, STEP

ELISA, WB, IHC-P, IF

90652859

Liquid