PTPN6 Antilichaam

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

5777

P29350

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human PTPN6 (NP_002822.2) .

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction

Affinity purification

BT-474

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 68kDa

IgG

PTPN6

MCF7

Mouse spleen

Protein tyrosine phosphatase, non-receptor type 6

Homo sapiens

SHP-1, protein tyrosine phosphatase, non-receptor type 6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, 70 kDa SHP-1L protein, hematopoietic cell phosphatase, hematopoietic cell protein-tyrosine phosphatase, protein-tyrosine phosphatase 1C, PTP1C

WB, IF

Liquid