PTX-35

PTX-35 is a human IgG monoclonal antibody (mAb) targeting TNFRSF25. PTX-35 reduces the suppressive activity of regulatory T cells and enhances CD4+ T cell effector responses in a mouse melanoma model. PTX-35 can be used in Islet cell transplant rejection and Solid tumours research. Recommended isotype control: Human IgG1 kappa, Isotype Control.

12352203

TNF Receptor

Apoptosis

Cancer-programmed cell death

Cancer

[3H][P][F,Cl,Br,I]

[1]Kalim K W, et al. PTX-35, a potential first-in-class TNFRSF25 agonist, reduced the suppressive activity of regulatory T cells and enhanced CD4+ T cell effector responses, in the presence of tumor antigens, in a murine melanoma model[J]. Cancer Research, 2021, 81 (13_Supplement) : 604-604.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P991455/

Inhibitory Antibodies

No Development Reported