PUF60 Antilichaam - C-terminal regio : HRP (ARP40760_T100-HRP)

Poly-U binding splicing factor 60KDa

FIR, VRJS, RoBPI, SIAHBP1

22827

Q9UHX1-2

NP_055096

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human PUF60

PUF60 is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription.The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.

ZG16; ARL8A; LOH12CR1; KIAA1683; MED28; QRICH1; UBE2I; SIAH1; SRSF11; SAP30BP; UPF2; KIAA0907; PUF60; U2AF2; SDCBP; RAD23B; CCNC; SUMO2; SUMO3; CDKN1A; UBC; ERG; EED; H3F3A; FAM129B; VPS29; FAF1; PAPOLA; NUDC; HIRIP3; ZYX; UGP2; TARS; TROVE2; PPM1G; PPP1R

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

PUF60 is supported by BioGPS gene expression data to be expressed in HeLa

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

58kDa

Gao, J., (2008) Genomics 91 (4), 347-355

Wet Ice

542

PUF60

PUF60

Rabbit

Poly (U) -binding-splicing factor PUF60

NM_014281

EIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYDQERFDNSDLSA