Purvalanol A
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests synchronized cells in G1 and G2 phase.2 Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3 Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4 In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5 Cell permeable.
Unconjugated
Pale green solid
-20°C
Beschrijving
Purvalanol A Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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