PVR-eiwit (C-human IgG1-Fc & AVI, menselijk)

PVR

CD155, HVED, Necl-5, NECL5, PVS, TAGE4

C-human IgG1-Fc & AVI

< 1.0 EU per μg protein as determined by the LAL method.

≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

1.Immobilized human TIGIT His (Cat: 10917-H08H) at 2 μg/mL (100 μl/well) can bind Human CD155/PVR (hFc & AVI Tag), Biotinylated (Cat: 10109-H41H-B), The EC50 of bind Human CD155/PVR (hFc & AVI Tag), Biotinylated (Cat: 10109-H41H-B) is 40-240 ng/mL (QC tested) . 2.Immobilized Recombinant Human CD226 Protein (Fc Tag) (Cat: 10565-H02H) at 2 μg/mL (100 μL/well) can bind Recombinant Human CD155 / PVR Protein (ECD, Fc & AVI Tag), Biotinylated (Cat: 10109-H41H-B), the EC50 is 8.2 ng/mL (Routinely tested) . 3.Serial dilutions of anti-TIGIT (Research Grade Tiragolumab biosimilar) were added into Recombinant Human TIGIT / VSTM3 Protein (His Tag) (Cat: 10917-H08H3) : Recombinant Human CD155 / PVR Protein (ECD, Fc & AVI Tag), Biotinylated (Cat: 10109-H41H-B) binding reactions. The half maximal inhibitory concentration (IC50) is 1014.8 ng/mL (Routinely tested) .

Met1-Asn343

The recombinant human PVR consists of 576 amino acids and predicts a molecular mass of 63.6 kDa. As a result of glycosylation, it migrates as an approximately 91.4 kDa band in SDS-PAGE under reducing conditions.

Human