PXR Antilichaam

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

8856

O75469

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human PXR (NP_071285.1) .

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Growth Factors, Signal Transduction, Transcription

Affinity purification

Rat liver

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 49kDa

IgG

NR1I2

Nuclear receptor subfamily 1, group I, member 2

Homo sapiens

NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR

WB, IHC

Liquid