PYHIN1 Antilichaam - N-terminalgebied: FITC (ARP50875_P050-FITC)

Pyrin and HIN domain family, member 1

IFIX

149628

Q6K0P9

NP_689714

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human PYHIN1

PYHIN1 belongs to the HIN-200 family. This protein is major mediator of the tumor suppressor activity of IFN in breast cancer cells. It promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization, and HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.

MDM2

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 91%; Dog: 91%; Horse: 91%; Human: 100%; Mouse: 100%; Pig: 85%; Rabbit: 93%; Rat: 85%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

55kDa

Ding, Y., (2006) Mol. Cell. Biol. 26 (5), 1979-1996

Wet Ice

492

PYHIN1

PYHIN1

Rabbit

Pyrin and HIN domain-containing protein 1

NM_152501

ANNYKKIVLLKGLEVINDYHFRIVKSLLSNDLKLNPKMKEEYDKIQIADL