Pyk2 (Phospho Tyr402) Antilichaam

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

2185

Q14289

NP_004094.3

Human, Mouse, Rat

Pyk2 (Phospho-Tyr402) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 402 (D-I-Y (p) -A-E) derived from Human Pyk2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

116 kDa

This antibody detects endogenous level of Pyk2 only when phosphorylated at tyrosine 402.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

PTK2B

Protein tyrosine kinase 2 beta

Homo sapiens

Gluck SL, et al. (2004) J Clin Invest; 114 (12) : 1696-1699Benzing T, et al. (2001) Proc Natl Acad Sci U S A; 98 (17) : 9784-9789Tian D, et al. (2002) Mol Cell Biol; 22 (8) : 2650-2662Lu Z, et al. (2001) Mol Cell Biol; 21 (12) : 4016-4031Krishnan HH, et al. (2006) J Virol; 80 (3) : 1167-1180

PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK, MAPTL, MTBT1, TAU, FADK 2, Focal adhesion kinase 2, PTK2B, Proline-rich tyrosine kinase 2 RAFTK

WB, IHC, IF

27886584

Liquid