Pyrazinediazooloxide (natrium)

Pyrazine diazohydroxide (NSC 361456) sodium is an anti-tumor agent that forms DNA adducts via the reactive pyrazine diazonium ion. Pyrazine diazohydroxide sodium can be used for the study of renal cancer, colorectal cancer, melanoma and leukemia[1][2].

103829-46-5

NSC-361456 (sodium)

12352005

DNA/RNA Synthesis

Cell Cycle/DNA Damage

Cancer

O=NNC1=NC=CN=C1.[Na]

C4H4N4NaO

147.09

[1]Harrison SD Jr, et al. Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo. Cancer Chemother Pharmacol. 1990;25 (6) :425-9.|[2]Vogelzang NJ, et al. Phase II and pharmacodynamic studies of pyrazine diazohydroxide (NSC 361456) in patients with advanced renal and colorectal cancer. Clin Cancer Res. 1998 Apr;4 (4) :929-34.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19045/

Reference compound1

No Development Reported