PZ-1129

PZ-1129 is a selective 5-HT7 receptor ligand with a Ki of 7 nM. PZ-1129 shows Ki values of 159 and 24 nM for 5-HT1A receptor and D2 receptor. PZ-1129 can inhibit the constitutive cAMP production mediated by the Gs signaling pathway (EC50 = 13.7 nM) . PZ-1129 can be used for the research of emotional disorders, such as depression and bipolar disorder[1].

1919029-61-0

12352005

5-HT Receptor; Dopamine Receptor

GPCR/G Protein; Neuronal Signaling

Neuroscience-Neuromodulation

Neurological Disease

O=S(NC1CCN(CC1)CCOC2=C(C3=CC=CC=C3)C=CC=C2)(C4=CC=C(C=C4)F)=O

C25H27FN2O3S

454.56

[1]Canale V, et al. Fine-tuning 5-HT7 receptor selectivity, inverse agonism, and metabolic stability of new (aryloxy) ethyl-piperidines toward antidepressant and pro-cognitive properties. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118369.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-179725/

Reference compound1

No Development Reported

5-HT1 Receptor;5-HT2 Receptor;5-HT6 Receptor;5-HT7 Receptor; D2 Receptor