QPH-FR

QPH-FR, a quinoa peptide, is a leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) inhibitor. QPH-FR competitively suppresses the formation of the LGR5/RSPO1 complex by binding to LGR5. QPH-FR causes RNF43/ZNRF3 to ubiquitinate the FZD receptor, thereby suppressing the Wnt/β-catenin signaling pathway and exerting stemness inhibition[1].

12352209

Wnt; β-catenin

Stem Cell/Wnt

Cancer-programmed cell death

Cancer

99.54

DMSO : 25 mg/mL (ultrasonic)

O=C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N3[C@@H](CCC3)C(NCC(NCC(NCC(NCC(NCC(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC4=CC=CC=C4)N

C81H124N26O25

1862.01

[1]Tian J, et al. QPH-FR: A Novel Quinoa Peptide Enhances Chemosensitivity by Targeting Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 in Colorectal Cancer. J Agric Food Chem. 2024 Aug 7;72 (31) :17417-17430.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10810/QPH-FR-SDS-MedChemExpress.pdf

Peptides

No Development Reported