QSOX1 Antilichaam

The QSOX1 gene, also known as Quiescin Q6, is a fusion of two ancient genes: thioredoxin and ERV1. Its expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation (1) . The QSOX1 protein oxidizes sulfhydryl groups to form disulfide bonds in proteins. QSOX1 expression is induced by hypoxia (2) and appears to protect cells against oxidative stress-induced apoptosis (3) .

5768

O00391

NP_002817

Human, Mouse

Unconjugated

Primary Antibodies

Cell Cycle, Cancer, Apoptosis

QSOX1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (76%)

QSOX1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

QSOX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

QSOX1 antibody is human and mouse reactive. QSOX1 antibody is predicted to not cross-react with QSOX2.

QSOX1

Cat. No. 10-901 - Human Spleen Tissue Slide

Quiescin Q6 sulfhydryl oxidase 1

Homo sapiens

Coppock DL, Cina-Poppe D, and Gilleran S. The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. Genomics 1998; 54:460-8.

Shi CY, Fan Y, Liu B, et al. HIF1 contributes to hypoxia-induced pancreatic cancer cells invasion via promoting QSOX1 expression. Cell Physiol. Biochem. 2013; 32:561-8.

Morel C, Adami P, Musard JF, et al. Involvement of sulfhydryl oxidase QSOX1 in the protection of cells against oxidative stress-induced apoptosis. Exp. Cell Res. 2007; 313:3971-82.

Quiescin Q6 sulfhydryl oxidase 1, Sulfhydryl oxidase 1, Q6, QSCN6

ELISA, WB, IHC-P, IF

13325075

Liquid