Quercëtine 4'-Glucoside-d3

Quercetin 4'-Glucoside-d3 (Spiraeoside-d3) is deuterium labeled Spiraeoside. Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities[1].

Spiraeoside-d3

12352005

Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

COVID-19-immunoregulation

Cancer; Inflammation/Immunology

O=C1C2=C(O)C=C(O)C=C2OC(C3=C([2H])C(O)=C(C([2H])=C3[2H])O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1[O]

C21H16D3O12

466.39

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hongyang Liu, et al. Spiraeoside protects human cardiomyocytes against high glucose-induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway. J Biochem Mol Toxicol. 2020 Oct;34 (10) :e22548.|[3]Stevan Samardžić, et al. Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. J Ethnopharmacol. 2018 Mar 1;213:132-137.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N8253S/

Isotope-Labeled Compounds

No Development Reported