Quinapril-d4

Quinapril-d4 (CI-906-d4) is deuterium labeled Quinapril. Quinapril is a potent, orally active, non-peptide and nonsulfhydryl inhibitor of angiotensin-converting enzyme (ACE) . Quinapril specifically interrupts the conversion of angiotensin I to angiotensin II in both plasma and tissue. Quinapril is enzymatically hydrolyzed to a pharmacologically active diacid form quinaprilat. Quinapril is efficacious in hypertensive models[1].

CI-906-d4

12352005

Angiotensin-converting Enzyme (ACE) ; Isotope-Labeled Compounds

Metabolic Enzyme/Protease; Others

Neuroscience-Neuromodulation

Cardiovascular Disease

CCOC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N2[C@@H](CC3=C([2H])C([2H])=C([2H])C([2H])=C3C2)C(O)=O)=O)=O

C25H26D4N2O5

442.54

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Kaplan HR, et, al. Quinapril--a preclinical review of the pharmacology, pharmacokinetics, and toxicology. Angiology. 1989 Apr;40 (4 Pt 2) :335-50.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0477AS2/

Isotope-Labeled Compounds

No Development Reported