(R) -Colchicine

(R) -Colchicine is the R-isomer of Colchicine. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID) -induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research[1][2][3][4][5].

75520-89-7

12352005

Apoptosis; Autophagy; Drug Isomer; Microtubule/Tubulin; NOD-like Receptor (NLR)

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Others

Inflammation/Immunology

COC1=C2C(C([C@@H](CCC2=CC(OC)=C1OC)NC(C)=O)=C3)=CC=C(OC)C3=O

C22H25NO6

399.44

[1]Bonfoco E, et al. Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res. 1995 May;218 (1) :189-200.|[2]Hastie SB. Interactions of colchicine with tubulin. Pharmacol Ther. 1991;51 (3) :377-401.|[3]Yuanjun Tang, et al. Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury. Front Pharmacol. 2021 Dec 16:12:804030.|[4]Otani K, et al. Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Sci Rep. 2016 Sep 2;6:32587.|[5]Carola Muñoz-Montesino, et al. Inhibition of the Glycine Receptor alpha 3 Function by Colchicine. Front Pharmacol. 2020 Jul 30;11:1143.|[6]Torin Huzil J, et al. Computational design and biological testing of highly cytotoxic colchicine ring A modifications. Chem Biol Drug Des. 2010 Jun;75 (6) :541-50.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W741136/

Reference compound1

No Development Reported