(R) -Doxazosine

(R) -Doxazosin ((R) -UK 33274) is an isomer of Doxazosin, a selective and orally active a1-adrenoceptor agonist. Doxazosin can be used for systemic antihypertensive and ocular hypotensive. Doxazosin exerts its antihypertensive effect by reducing total peripheral resistance by selective postsynaptic a1-blockade, without reducing cardiac output. Doxazosin can significantly lower both standing and supine blood pressure[1].

70918-17-1

(R) -UK 33274

12352005

H315-H319-H320

Adrenergic Receptor

GPCR/G Protein; Neuronal Signaling

Metabolic Disease

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)[C@@H]4OC5=CC=CC=C5OC4

C23H25N5O5

451.48

P264-P280-P302+P352-P305+P351+P338-P362

[1]Young, R. A., & Brogden, R. N. (1988) . Doxazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension. Drugs, 35 (5), 525–541.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0098B/

Reference compound1

No Development Reported