R-MA-SLM

R-MA-SLM is an Aβ-targeted and blood-brain barrier-permeable ratiometric H2O2-responsive fluorescent probe. When excited at 490 nm, the fluorescence intensity of the R-MA-SLM gradually decreases at 574 nm, while the emission intensity gradually increases at 661 nm. R-MA-SLM can detect and exhibits a ratiometric response to Aβ-induced endogenous H2O2. R-MA-SLM can be used in the research of Alzheimer's disease[1].

12352005

Amyloid-β; Fluorescent Dye

Neuronal Signaling; Others

Neurological Disease

O=C(N(C1=CC=C(C=C1)/C=C/C2=C3C=CC=CC3=[N+](C)C=C2)C)OCC4=CC=C(B5OC(C)(C)C(C)(C)O5)C=C4.[I-]

C33H36BIN2O4

662.37

[1]Wang X, et al. Real-Time Detection and Visualization of Amyloid-β Aggregates Induced by Hydrogen Peroxide in Cell and Mouse Models of Alzheimer's Disease. ACS Appl Mater Interfaces. 2023 Jan 11;15 (1) :39-47.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-D2963/

Dye Reagents

No Development Reported