(R) -Pantetheine-d4

(R) -Pantetheine-d4 (Pantetheine-d4) is the deuterium labeled (R) -Pantetheine. (R) -Pantetheine is the biosynthetic precursor to CoA. (R) -Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R) -Pantetheine has high toxicity[1][2][3].

Pantetheine-d4

12352211

Endogenous Metabolite; Isotope-Labeled Compounds

Metabolic Enzyme/Protease; Others

Metabolic Disease

OCC(C)([C@H](C(NCCC(NC([2H])(C([2H])(S)[2H])[2H])=O)=O)O)C

C11H18D4N2O4S

282.39

[1]Rothmann M, et al. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. J Am Chem Soc. 2013 Apr 24;135 (16) :5962-5.|[2]Wang Y, et al. Ligand supplementation restores the cancer therapy efficacy of an antirheumatic drug auranofin from serum inactivation. bioRxiv, 2024: 2024.01. 25.577173.|[3]Moretto L, et al. Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates. Chem Commun (Camb) . 2017 Oct 25;53 (83) :11457-11460.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W719281/

Isotope-Labeled Compounds

No Development Reported