(R, S, S) -Dihydrotetrabenazine

(R, S, S) -Dihydrotetrabenazine (R, S, S-DHTBZ) is a kind of discrete isomeric secondary alcohol metabolites of Tetrabenazine (TBZ, HY-B0590), is a poor VMAT2 inhibitor (Ki = 690 nM).

924854-62-6

R, S, S-DHTBZ

12352005

H302, H315, H319, H335

Drug Metabolite; Monoamine Transporter

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Neurological Disease

98.95

DMSO : 100 mg/mL (ultrasonic)

[H][C@@]12C[C@H]([C@H](CN1CCC3=C2C=C(C(OC)=C3)OC)CC(C)C)O

C19H29NO3

319.44

H302, H315, H319, H335

[1]Dimitri E Grigoriadis, et al. Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites. J Pharmacol Exp Ther. 2017 Jun;361 (3) :454-461.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W681822/R-S-S-Dihydrotetrabenazine-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported