RAB1B-eiwit, menselijk, recombinant (hFc)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells. Moreover, down-regulation of RAB1B was also found to promote the proliferation and migration of TNBC cells in vitro and in vivo. Mechanistically, loss of RAB1B resulted in elevated expression of TGF-beta receptor 1 (TbetaR1) through decreased degradation of ubiquitin, increased levels of phosphorylated SMAD3 and TGF-beta-induced epithelial-mesenchymal transition (EMT) . Furthermore, low RAB1B expression correlated with poor prognosis in breast cancer patients.RAB1B acts as a metastasis suppressor in TNBC by regulating the TGF-beta/SMAD signaling pathway and RAB1B may serve as a novel biomarker of prognosis and the response to anti-tumor therapeutics for patients with TNBC.
Ice Packs
-20°C
Beschrijving
RAB1B-eiwit, menselijk, recombinant (hFc) Beschikbaar in 5 µg. Bestel eenvoudig online met snelle levering.
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