RAB21 Antilichaam

RAB21 Antibody: RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER) -like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the α -tail of endocytosed integrin.

23011

Q9UL25

NP_055814

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

RAB21 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1405 - Mouse Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (95%)

RAB21 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RAB21 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

This antibody is predicted to not cross-react with other Ras-related proteins

RAB21

Cat. No. 10-401 - Human Kidney Tissue Slide

RAB21, member RAS oncogene family

Homo sapiens

Opdam FJ, Kamps G, Croes H, et al. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. Eur. J. Cell Biol. 2000; 79:308-16.

Pellinen T and Ivaska J. Integrin traffic. J. Cell Sci. 2006; 119:3723-31.

Mai A, Veltel S, Pellinen T, et al. Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration. J. Cell Biol. 2011; 194:291-306.

RAB21 Antibody: KIAA0118, Ras-related protein Rab-21

ELISA, WB, IF

7661922

Liquid