Rab25 Antilichaam [3F12F3]

Members of the Ras-related superfamily of GTP binding proteins, which includes Ras, Rho, Rab and ARF subfamilies, exhibit 30-50% similarity with Ras p21. Rab proteins play an important role for either in endocytosis or in biosynthetic protein transport. The possibility that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% similar to Rab proteins, is associated with secretory vesicles. Rab proteins located on the cytoplasmic face of organelles and vesicles, rab proteins are involved in intracellular membrane fusion reactions. Rab25 was cloned from a gastric parietal cell cDNA library and is expressed in epithelial tissues such as the gastrointestinal mucosae, kidney, and lung, which encoded a protein of 28 kDa.

57111

P57735

P57735

Human

Ni-NTA purified recombinant Rab25 expressed in E. Coli strain BL21 (DE3) .

3F12F3

Unconjugated

Primary Antibodies

Signal Transduction

Antibody is purified by protein A affinity chromatography and resuspended in PBS with 0.2%BSA, 0.09% sodium azide.

Batch dependent

Purified antibody in PBS containing 0.03% sodium azide.

None

Blue Ice

Rab25 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG2a

RAB25

RAB25, member RAS oncogene family

Homo sapiens

JR Goldenring, KR Shen, HD Vaughan. et al. J. Biol. Chem,1993,268 (25) :18419-18422

Xiaoye W, Ravindra K, Jennifer N. et al. J. Biol. Chem,2000,275 (37) :29138-29146

CATX8, CATX-8CATX-8, RAB11C

ELISA, WB, IHC

46577696