RABEX5 Antilichaam

RABEX5 Antibody: RABEX5 is a guanine nucleotide exchange factor (GEF) that forms a complex with rabaptin-5 and specifically activates Rab5, a small GTPase that plays an essential role in endocytic traffic. RABEX-5 is thought to also interact with another member of the Rab family, Rab22, which targets RABEX5 to early endosomes, allowing it to activate Rab5 and thereby promote Rab5-mediated endosome fusion.

27342

Q9UJ41

NP_055319

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

RABEX5 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1304 - Human Liver Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

RABEX5 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RABEX5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least four isoforms of RABEX5 are known to exist; this antibody will recognize all four. RABEX5 antibody is predicted to not cross-react with other LRRFIP family members.

RABGEF1

RAB guanine nucleotide exchange factor (GEF) 1

Homo sapiens

Horiuchi H, Lippe R, McBride HM, et al. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell 1997; 90:1149-59.

Zhu H, Liang Z, and Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Mol. Biol. Cell 2009; 20:4720-9.

RABEX5 Antibody: RAP1, RABEX5, rabex-5, RAP1

ELISA, WB, IHC-P, IF

7657496

Liquid