(rac) -Poriol

(rac) -Poriol (5,7,4'-Trihydroxy-6-methylflavanone) exhibits antioxidant activity, and scavenges free radical DPPH with an IC50 of 0.18 µg/mL. (rac) -Poriol inhibits the LPS -induced NO generation in RAW264.7 (98.35% inhibition rate at 10 μM), and exhibits anti-inflammatory activity. (rac) -Poriol exhibits good binding affinity with iNOS, COX-1, COX-2, TNF-α, and IL-1β[1].

70460-58-1

5,7,4'-Trihydroxy-6-methylflavanone

12352005

COX; Interleukin Related; NO Synthase

Immunology/Inflammation

COVID-19-immunoregulation

Inflammation/Immunology

O=C1C2=C(C(C)=C(C=C2OC(C1)C3=CC=C(C=C3)O)O)O

C16H14O5

286.28

[1]Sucahyo A, et al. Flavanones from ethyl acetate fraction of Caesalpinia sappan heartwood as anti-inflammatory and antioxidant: Isolation, in-vitro, and in-silico approach[C]//AIP Conference Proceedings. AIP Publishing, 2024, 3055 (1) .

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N9086A/

Natural Products

No Development Reported