RAD18 Antilichaam - middengebied: FITC (ARP43266_P050-FITC)

RAD18 homolog (S. cerevisiae)

RNF73

56852

Q9NS91

NP_064550

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human RAD18

RAD18 is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, RAD18 is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

TAX1BP1; UBC; SHPRH; RAD18; SIVA1; USP2; UBE2B; UBE2A; HLTF; PCNA; BPLF1; USP5; DBF4; BRCA1; DZIP3; POLH; DTL; Ankrd32; MLKL; ECT2; RPL10A; TRIM23; PCGF6; TRIM8; RFC2; CPD; SPRTN; ZMYM2; MAPK8; POLN; WRNIP1; gag-pol; ORC2; SUMO2; POLK; NBN; Smc6; HIST1H2A

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 86%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

56kDa

Tsuji, Y., (2008) Genes Cells 13 (4), 343-354

Wet Ice

495

RAD18

RAD18

Rabbit

E3 ubiquitin-protein ligase RAD18

NM_020165

KQVTKVDCPVCGVNIPESHINKHLDSCLSREEKKESLRSSVHKRKPLPKT