RAD23B Antilichaam

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER) . This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

5887

P54727

Human, Mouse

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human RAD23B (NP_002865.1) .

Unconjugated

Primary Antibodies

Other

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 80kDa

IgG

RAD23B

Jurkat

SKOV3

Mouse testis

Mouse brain

Mouse liver

RAD23 homolog B, nucleotide excision repair protein

Homo sapiens

HHR23B, HR23B, P58, UV excision repair protein RAD23 homolog B, RAD23, yeast homolog of, B, XP-C repair complementing complex 58 kDa, XP-C repair complementing protein, XP-C repair-complementing complex 58 kDa protein

WB, IHC, IF

Liquid