RAD50 Antilichaam

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

10111

Q92878

Human, Mouse

A synthetic peptide of human RAD50

Unconjugated

Primary Antibodies

Cell Cycle

Affinity purification

NIH3T3

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 180kDa

IgG

RAD50

MCF-7

A-549

HT-29

Mouse lung

RAD50 homolog (S. cerevisiae)

Homo sapiens

DNA repair protein RAD50, hRAD50, NBSLD, RAD502, hRad50

WB, IHC, IF

Liquid