RAGEF2 Polyklonale Antilichaam, PE-vervoeging

RAPGEF6 is a guanine nucleotide exchange factor (GEF) that is expressed in a variety of tissues. Localizing to the cytoplasm and translocated to the plasma membrane upon ligand binding, RAPGEF6 contains an N-terminal Ras-GEF domain, a cyclic nucleotide monophosphate-binding domain, a PDZ (PSD-95/DlgA/ZO-1) domain, a Ras-associating (RA) domain and a Ras exchanger motif. RAPGEF6 is closely related to RAPGEF2 and both proteins exhibit GEF activity specific towards Rap 1 and Rap 2. In addition, RAPGEF6 is capable of binding to M-Ras via its RA domain. Due to alternative splicing events, two additional isoforms exist for RAPGEF6, namely PDZ-GEF2A and PDZ-GEF2B.

DKFZp667N084; DKFZp686I15116; KIA001LB; PDZ domain containing guanine nucleotide exchange factor GEF 2; PDZ domain containing guanine nucleotide exchange factor 2; PDZ domain containing guanine nucleotide exchange factor I; PDZ domain-containing guanine nucleotide exchange factor 2; PDZ GEF 2; PDZ GEF2; PDZ-GEF2; PDZGEF 2; PDZGEF2; RA GEF 2; RA GEF2; RA-GEF-2; RAGEF 2; Rap guanine nucleotide exchange factor GEF 6; Rap guanine nucleotide exchange factor 2; Rap guanine nucleotide exchange factor 6; RAPGEF6; RPGF6_HUMAN.

Cytoplasm, Cell membrane

601-700/1601

RAGEF2

PE

KLH conjugated synthetic peptide derived from human RAGEF2

IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

496,564nm/578nm

1µg/µl

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Human, Rabbit