RAIDD Antilichaam

RAIDD Antibody: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD) -containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD) 1, RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals1, 3. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.

8738

P78560

AAB42217

Human

Unconjugated

Primary Antibodies

Apoptosis, Cancer

RAIDD Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/ml

Predicted species reactivity based on immunogen sequence: Mouse: (78%)

RAIDD Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RAIDD antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

22 kDa

IgG

CRADD

Cat. No. 1204 - K562 Cell Lysate

Cat. No. 17-001 - HeLa Cell Slide

CASP2 and RIPK1 domain containing adaptor with death domain

Homo sapiens

Duan H, Dixit VM. RAIDD is a new 'death' adaptor molecule. Nature 1997;385:86-89

Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res 1997 57:615-619

Hofmann K, Bucher P, Tschopp J. The CARD domain: a new apoptotic signalling motif. Trends Biochem Sci 1997;22:155-156 (RD1299)

RAIDD Antibody: MRT34, RAIDD, Death domain-containing protein CRADD, Caspase and RIP adapter with death domain

ELISA, WB, ICC, IF

1785557

Liquid