RANBP10 Antilichaam

RANBP10 Antibody: The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets where it localizes to polymerized noncentrosomal microtubules. RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase, suggesting that RANBP10 may also be involved in these activities. RANBP10 depletion in vitro caused the disturbance of polymerized filaments in MKs and platelets in RANBP10-null mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.

57610

Q6VN20

EAW83167

Human

Unconjugated

Primary Antibodies

Homeostasis

RANBP10 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (93%), Mouse: (87%)

RANBP10 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RANBP10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

RANBP10

RAN binding protein 10

Homo sapiens

Wang D, Zaibo Li, Schoen SR, et al. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/ERK signaling. Biochem. Biophys. Res. Comm.2004; 313:320-6.

Schulze H, Dose M, Korpal M, et al. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J. Biol. Chem.2008; 283:14109-19.

Dasso M. The Ran GTPase: theme and variations. Curr. Biol.2002; R502-8.

Kunert S, Meyer I, Fleischhauer S, et al. The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Blood2009; 114:5532-40.

RANBP10 Antibody: KIAA1464, Ran-binding protein 10, RanBP10

ELISA, WB, IHC-P, IF

119603573

Liquid