RANTES (CCL 5)

RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV) . Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

CCL5; SISd; SCYA5; RANTES; TCP228; D17S136E

6352

P13501

NP_002976.2

NM_002985

17q11.2-q12

Human

Cow, Hamster, Monkey, Mouse, Rat, Human, Leech, Bacteria

SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to chemoattract human blood monocytes using a concentration range of 1.0-10.0 ng/ml.

68

Lyophilized

7.8 kDa

E. coli