RAP1A Antilichaam

This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs) . The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants.

5906

P62834

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human RAP1A (NP_002875.1) .

Unconjugated

Primary Antibodies

Immunology, Signal Transduction

Affinity purification

U-87MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 21kDa

IgG

RAP1A

HL-60

Mouse lung

Mouse kidney

Rat kidney

Rat brain

Ras-related protein Rap-1A

Homo sapiens

Ras-related protein Rap-1A, C21KG, G-22K, GTP-binding protein smg p21A, Ras-related protein Krev-1, RAP1A, KREV1

WB, IHC, IF

Liquid