RASAL1 Antilichaam

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described

8437

O95294

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 120-340 of human RASAL1 (NP_004649.2) .

Unconjugated

Primary Antibodies

Cancer, Signal Transduction

Affinity purification

A549

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 110kDa

IgG

WB: 1:500 - 1:2000

RASAL1

MCF7

Mouse brain

Rat brain

RAS protein activator like 1 (GAP1 like)

Homo sapiens

RASAL1, RASAL, RAS protein activator like 1 (GAP1 like), GAP1 like protein, RAS-GTPase-activating protein-like

WB

Liquid