RASSF1 Antilichaam

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

11186

Q9NS23

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 101-340 of human RASSF1 (NP_009113.3) .

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle, Signal Transduction

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 39kDa

IgG

RASSF1

HepG2

293T

SW480

Ras association domain-containing protein 1

Homo sapiens

Ras association domain-containing protein 1, RASSF1 {ECO:0000312|EMBL:AAF351282}

WB, IF

Liquid