RASSF1 Mouse Monoclonal Antibody [Kloon ID: LBI2B11]

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Carrier-free (BSA/glycerol-free) RASSF1 mouse monoclonal antibody, clone LBI2B11

123F2; NORE2A; RASSF1A; RDA32; REH3P21

Homo sapiens Ras association domain family member 1 (RASSF1), transcript variant A, mRNA.

11186

Q9NS23

Unconjugated

Bladder cancer, Non-small cell lung cancer, Pathways in cancer

Bladder cancer, Non-small cell lung cancer, Pathways in cancer

WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

RASSF1

https://www.ncbi.nlm.nih.gov/gene/?term=11186

https://www.uniprot.org/uniprot/Q9NS23