RB-105

RB-105 is an inhibitor of angiotensin-converting enzyme (ACE) (Ki = 4.2 nM) and neutral endopeptidase (NEP) (Ki = 1.7 nM) . RB-105 after inhibiting ACE reduces the production of Ang II and increase the level of bradykinin. RB-105 after inhibiting NEP increases the level of natriuretic peptide and further increases the level of bradykinin, thereby generating a powerful synergistic effect. RB-105 has significant antihypertensive and natriuretic effects in both spontaneously hypertensive rats and normal blood pressure rats. RB-105 can be used for research on hypertension[1].

155895-89-9

12352005

Angiotensin-converting Enzyme (ACE) ; Neprilysin

Metabolic Enzyme/Protease

Cardiovascular Disease

C[C@@H](C(O)=O)NC([C@@H](CS)[C@H](C1=CC=CC=C1)C)=O

C14H19NO3S

281.37

[1]Gonzalez Vera W, et al. Hypotensive and natriuretic effects of RB 105, a new dual inhibitor of angiotensin converting enzyme and neutral endopeptidase in hypertensive rats. J Pharmacol Exp Ther. 1995 Jan;272 (1) :343-51.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19200/

Reference compound1

No Development Reported

ACE