Rb Antilichaam

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

5925

P06400

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 701-928 of human Rb (NP_000312.2) .

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Transcription

Affinity purification

K-562

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 110kDa

IgG

RB1

Retinoblastoma 1

Homo sapiens

RB1, RB, pRb, OSRC, pp110, p105-Rb

WB, IF

Liquid